Causes Fibrodysplasia Ossificans Progressiva (FOP)

The basic genetic error is a mutation in the activin receptor IA (ACVR1) gene.

In most affected patients worldwide an identical mutation is found and this mutation is not present in the parents and has occurred at the moment of conception. In this situation the chances of recurrence in the family are negligible.

For a person with FOP, however, there will be a one in two chance of handing on the condition to any children.

Further information on this point may be obtained from your local genetic counselling clinic.