Understanding the role of KY protein in muscle

Dr Gonzalo Blanco at the University of York will investigate the function of a muscle protein called KY. This research will improve our understanding of muscle biology and how this is affected in a type of congenital myopathy.

What are the aims of the project?

This project aims to gain a better understanding of a muscle protein called KYphoscoliosis peptidase (KY).

Why is this research important?

We know that KY is significant to muscle, because when it’s missing in mice and people this results in a myopathy. But exactly what the protein does has not yet been established, and we need to understand this to be able to think about possible treatments. Knowing more about KY will also improve our general understanding of muscle biology, which could be helpful for future research into other conditions.

What will the researchers do?

Finding out the structure of proteins can tell us a bit about what they do. The researchers will investigate the structure of KY using a technique called X-ray crystallography. This involves firing X-rays at the protein, which then bounce back into a detector. A connecting computer then uses this information to form a 3D image of the protein. This will be compared to proteins of known function, so the researchers can see if there are any similarities.

The researchers will also investigate where KY is located inside muscle cells, and what other proteins it interacts with. This information, together with the 3D analysis, will help to determine the function of KY.

Grant information

Project leader: Dr Gonzalo Blanco
Institute: University of York
Condition: Congenital myopathy
Duration: Two years
Total cost (£): 37495
Official title: The function of the KY protein in early onset neuromuscular disease

For further information

If you would like further details about this research project, please contact the MDUK Research Line on 02078034813 or email research@musculardystrophyuk.org

It is only through your contributions that we can continue to fund the vital work that takes us closer to finding treatments and cures for muscle-wasting conditions. Donate now and help change the lives of thousands of people living with these conditions. Thank you for your support.

Keep in touch