Missing protein restored by scientists

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  • #75352
    Missing protein restored by scientists

    I got sent this yesterday, quite an achievement I think!

    article from sciencedaily.com

    A learning experience is one of those things that say, “You know that thing you just did? Don’t do that.” - Douglas Adams

    sar78 sar78
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    #94568
    Re: Missing protein restored by scientists

    hmm interesting. lets hope it works

    stefan

    littlestef
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    #94569
    Re: Missing protein restored by scientists

    Loved the hope of the article and the obvious benefits as shown in the three graphics …… concerned that it will give too much hope to those hanging onto a cure and soon ….. long way to go but it certainly looks positive :yes:

    I'm always the animal, my body's the cage

    I blog about nothingness www.amgroves.com

    AM
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    #94570
    Re: Missing protein restored by scientists

    Yes, I agree this a significant step but there is such a long way to go. I think it is encouraging to know that these little steps are continuing to be made. In my lifetime, so much more has been discovered within my condition CMD but it is important to be mindful that a lot more is yet to be understood.

    A learning experience is one of those things that say, “You know that thing you just did? Don’t do that.” - Douglas Adams

    sar78 sar78
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    #94571
    Re: Missing protein restored by scientists

    nice to have hope of a future cure. nice that they are still thinking of us and working towards possible therapies etc for if not us but future generations. ever hopeful

    """""""What doesn't kill you makes you stronger""""""

    Cat (Mod) Cat (Mod)
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    #94572
    Re: Missing protein restored by scientists

    I see this research was aimed at restoring protein where there is a dysferlin mutation. I know absolutely nothing about this condition but I wondered if the principle they are applying could possibly apply to others such as Duchenne’s – or is it only applicable to this particular mutation?

    Lesley
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    Joined: 28/11/2010
    #94573
    Re: Missing protein restored by scientists

    Interesting question Lesley.

    Dysferlin also known as dystrophy-associated fer-1-like protein is a protein that in humans is encoded by the DYSF gene. Dysferlin is linked with skeletal muscle repair, the resealing of cell membrane. It is not part of all MD’s but some such as Limb-Girdle. I have done some preliminary reading and Duchenne is not mentioned specifically in articles about this protein.

    Dystrophin is a protein located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). It is a cohesive protein, linking actin filaments to another support protein that resides on the inside surface of each muscle fiber’s plasma membrane (sarcolemma). So not just present in skeletal muscles but all muscle types. It is mutations in the dystrophin gene that causes specific MD’s like DMD and BMD.

    The two proteins have different jobs, Dysferlin is involved with cell membrane repair, where as Dystrophin acts like a sticky chain linking three proteins together. Far more is known about the actions of Dystrophin than Dysferlin. Point-of-principal breakthroughs are always exciting, because as you ask, it could help move research forward in other conditions not just the Dysferlin-deficient ones.

    I'm always the animal, my body's the cage

    I blog about nothingness www.amgroves.com

    AM
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    #94574
    Re: Missing protein restored by scientists

    Thank you very much for such a detailed reply. When family members mention this research breakthrough I can now at least tell them it doesn’t apply to Duchennes at this stage. But of course it’s a fantastic achievement and such good news for those to whom it applies. We all need some hope!

    Lesley
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    #94575
    Re: Missing protein restored by scientists

    :yes:

    Nowerdays research has to get to the nitty-gritty minutia to try and understand it, figure out the why, work on how to stop/reverse/replace it and then try and work out hot to get that stop/reverse/repair i place to work …. nothing is as straight forward as taking a pill anymore.

    Slowly but surely, there has been so much advancement of understanding in just the last 30 years.

    I'm always the animal, my body's the cage

    I blog about nothingness www.amgroves.com

    AM
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