Myotonic dystrophy is a genetic condition that causes progressive muscle weakness and wasting. It typically affects muscles of movement and, commonly, the electrical conduction system of the heart, breathing muscles, swallowing muscles, bowels, lens of the eye, and brain.
One issue for people with type-1 myotonic dystrophy is imbalance, which is associated with a high risk of falls. The key factors that cause imbalance are poorly understood.
What are the aims of the project?
Dr Kaski aims to make a comprehensive and detailed assessment of balance in patients with type-1 myotonic dystrophy, using electromyography (a standard technique used to measure muscle function in people with neuromuscular conditions), and 3D motion capture. The results of these studies will be compared with data from subjects who do not have myotonic dystrophy.
Why is this research important?
This study will contribute to a better understanding of imbalance in people with type-1 myotonic dystrophy. The study may help to identify biomarkers (measurements that can be used to determine prognosis or can be used in clinical trials) of fall risk in patients with type-1 myotonic dystrophy.