Even though there is no cure for myofibrillar myopathies, individuals affected by arrhythmia and/or cardiac conduction defects or cardiomyopathy may consider implantation of a pacemaker and cardioverter-defibrillator (ICD).
Heart transplantation may be considered if the cardiomyopathy is progressive or life-threatening.
Assisted ventilation and physiotherapy may be helpful for those with advanced muscle weakness.
Orthotics and other walking aids may be helpful, for example if foot drop develops.